Title : Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.

Pub. Date : 2017 Jul

PMID : 28346693






2 Functional Relationships(s)
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1 ARQ761 undergoes a robust, futile redox cycle in NQO1+ cancer cells, producing massive hydrogen peroxide (H2 O2 ) levels; normal tissues are spared by low NQO1 and high catalase expression. Hydrogen Peroxide NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 ARQ761 undergoes a robust, futile redox cycle in NQO1+ cancer cells, producing massive hydrogen peroxide (H2 O2 ) levels; normal tissues are spared by low NQO1 and high catalase expression. Hydrogen Peroxide NAD(P)H quinone dehydrogenase 1 Homo sapiens