Title : Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.

Pub. Date : 2017 May 1

PMID : 28346230






1 Functional Relationships(s)
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1 Here we have shown that VHL-/- RCC cells rely on RC-derived aspartate to maintain de novo pyrimidine biosynthesis. pyrimidine von Hippel-Lindau tumor suppressor Homo sapiens