Title : Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.

Pub. Date : 2017 May 19

PMID : 28341741






3 Functional Relationships(s)
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1 LPS-induced p38 MAPK and NF-kappaB activations were necessary for both IL-33 production and PGE2 generation, and exogenous PGE2 partly reversed the suppression of IL-33 production caused by p38 MAPK and NF-kappaB inhibition. Dinoprostone mitogen-activated protein kinase 14 Mus musculus
2 LPS-induced p38 MAPK and NF-kappaB activations were necessary for both IL-33 production and PGE2 generation, and exogenous PGE2 partly reversed the suppression of IL-33 production caused by p38 MAPK and NF-kappaB inhibition. Dinoprostone mitogen-activated protein kinase 14 Mus musculus
3 LPS-induced p38 MAPK and NF-kappaB activations were necessary for both IL-33 production and PGE2 generation, and exogenous PGE2 partly reversed the suppression of IL-33 production caused by p38 MAPK and NF-kappaB inhibition. Dinoprostone mitogen-activated protein kinase 14 Mus musculus