Pub. Date : 2017 Jun 1
PMID : 28339691
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 2 | Background: Z-guggulsterone, an active compound extracted from the gum resin of the tree Commiphora mukul, has been shown to improve animal memory deficits via activating the brain-derived neurotrophic factor signaling pathway. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 3 | Z-guggulsterone (10, 30 mg/kg) administration prevented the reductions in brain-derived neurotrophic factor protein expression levels as well as the phosphorylation levels of cAMP response element binding protein, extracellular signal-regulated kinase 1/2, and protein kinase B in the hippocampus and cortex induced by chronic unpredictable stress. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 4 | Blockade of the brain-derived neurotrophic factor signal, but not the monoaminergic system, attenuated the antidepressant-like effects of Z-guggulsterone. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |
| 5 | Conclusions: Z-guggulsterone exhibits antidepressant activity via activation of the brain-derived neurotrophic factor signaling pathway and upregulation of hippocampal neurogenesis. | pregna-4,17-diene-3,16-dione | brain derived neurotrophic factor | Mus musculus |