Pub. Date : 2017 Mar 23
PMID : 28337024
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Angiotensin II promotes the anticoagulant effects of rivaroxaban via angiotensin type 2 receptor signaling in mice. | Rivaroxaban | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | In this study, we investigate whether AngII influences anticoagulant effects of rivaroxaban by using an experimental mouse model with type 2 diabetes mellitus and advanced glycation end product (AGE)-exposed human umbilical vein endothelial cells (HUVECs). | Rivaroxaban | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | We found that AngII promoted the anticoagulant effects of rivaroxaban in KKAy mice. | Rivaroxaban | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 4 | Angiotensin type 2 receptor (AT2R) and Mas antagonists attenuated the AngII-enhanced anticoagulant action of rivaroxaban in vivo, and abolished the increased endothelial TFPI expression and activity. | Rivaroxaban | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 5 | Our data suggest that the anticoagulant effects of rivaroxaban are promoted by AngII via AT2R and Mas signaling. | Rivaroxaban | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |