Title : The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling.

Pub. Date : 2017 Mar 22

PMID : 28331185






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Loss of podocytes can occur as a result of excessive intracellular calcium influx, and we have previously shown that angiotensin II (Ang II) via canonical transient receptor potential 6 (TRPC6) channels caused increased intracellular Ca2+ flux in podocytes. Calcium angiotensinogen Homo sapiens
2 Loss of podocytes can occur as a result of excessive intracellular calcium influx, and we have previously shown that angiotensin II (Ang II) via canonical transient receptor potential 6 (TRPC6) channels caused increased intracellular Ca2+ flux in podocytes. Calcium angiotensinogen Homo sapiens
3 We showed here with patch-clamp electrophysiology that Ang II activates TRPC channels; then using confocal calcium imaging we demonstrated that Ang II-dependent stimulation of Ca2+ influx in the podocytes is precluded by blocking either AT1 or AT2 receptors (ATRs). Calcium angiotensinogen Homo sapiens
4 Ang II-induced calcium flux was decreased upon inhibition of TRPC channels with SAR7334, SKF 96365, clemizole hydrochloride and La3+, but not ML204. Calcium angiotensinogen Homo sapiens