Title : Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.

Pub. Date : 2017 May 12

PMID : 28330869






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes. NADP isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes. NADP isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
3 IDH1 mutations typically result in a loss of catalytic activity, but many also can catalyze a new reaction, the NADPH-dependent reduction of alphaKG to d-2-hydroxyglutarate (D2HG). NADP isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens