Title : Retinoic acid combined with spermatogonial stem cell conditions facilitate the generation of mouse germ-like cells.

Pub. Date : 2017 Apr 30

PMID : 28314787






2 Functional Relationships(s)
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1 Interestingly, addition of retinoic acid (RA) into SSC conditions enabled efficient differentiation of mouse ESCs into germ-like cells, as shown by the activation of spermatogenesis-associated genes such as Mvh, Dazl, Prdm14, Stella, Scp1, Scp3, Stra8 and Rec8 In contrast, for cells cultured in control medium, the activation of the above genes barely occurred. Tretinoin stimulated by retinoic acid gene 8 Mus musculus
2 Interestingly, addition of retinoic acid (RA) into SSC conditions enabled efficient differentiation of mouse ESCs into germ-like cells, as shown by the activation of spermatogenesis-associated genes such as Mvh, Dazl, Prdm14, Stella, Scp1, Scp3, Stra8 and Rec8 In contrast, for cells cultured in control medium, the activation of the above genes barely occurred. Tretinoin stimulated by retinoic acid gene 8 Mus musculus