Title : Protein kinase C enhances Ca2+ mobilization in human platelets by activating Na+/H+ exchange.

Pub. Date : 1988 Mar 25

PMID : 2831223






1 Functional Relationships(s)
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1 Several observations indicate that the exchanger is regulated by protein kinase C. (i) Inhibitors of protein kinase C (trifluoperazine, sphingosine) inhibit the increase in pHi seen during thrombin stimulation as well as Ca2+ mobilization; artificially increasing pHi by monensin or NH4Cl then restores Ca2+ mobilization. Ammonium Chloride coagulation factor II, thrombin Homo sapiens