Title : Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product.

Pub. Date : 1988 Feb 19

PMID : 2829972






2 Functional Relationships(s)
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1 The enzymatic conversion of leukotriene A4 into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid, catalyzed by mouse liver cytosolic epoxide hydrolase (EC 3.3.2.3), was recently described (Haeggstrom, J., Meijer, J. and Radmark, O. Leukotriene A4 epoxide hydrolase 2, cytoplasmic Mus musculus
2 Also, a semipurified preparation of human liver cytosolic epoxide hydrolase avidly catalyzed the same hydrolysis of leukotriene A4 (apparent Km was 8 microM). Leukotriene A4 epoxide hydrolase 2, cytoplasmic Mus musculus