Title : Phospholipid environment alters hormone-sensitivity of the purified insulin receptor kinase.

Pub. Date : 1987 Dec 15

PMID : 2829843






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Reconstitution of the receptor kinase into leaky vesicles containing phosphatidylcholine and phosphatidylethanolamine (1:1, w/w) by detergent removal on Sephadex G-50 results in the complete loss of receptor kinase sensitivity to activation by insulin. Phosphatidylcholines insulin Homo sapiens
2 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. Phosphatidylcholines insulin Homo sapiens
3 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. Phosphatidylcholines insulin Homo sapiens