Title : Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate.

Pub. Date : 2017 Jul

PMID : 28295625






3 Functional Relationships(s)
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1 Ambroxol is a small molecule chaperone that has been shown in mice to cross the blood-brain barrier, increase GCase activity and reduce alpha-synuclein protein levels. Ambroxol glucosidase, beta, acid Mus musculus
2 In this study, we analyze the effect of ambroxol treatment on GCase activity in healthy nonhuman primates. Ambroxol glucosidase, beta, acid Mus musculus
3 We show that daily administration of ambroxol results in increased brain GCase activity. Ambroxol glucosidase, beta, acid Mus musculus