Title : Potential Mechanisms of Hematological Adverse Drug Reactions in Patients Receiving Clozapine in Combination With Proton Pump Inhibitors.

Pub. Date : 2017 Mar

PMID : 28291036






2 Functional Relationships(s)
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Protein Name
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1 Formation of N-desmethylclozapine is correlated with activity of the cytochrome P450 enzymes 1A2 and 3A4 (CYP1A2 and CYP3A4). norclozapine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 Moreover, induction of CYP1A2, especially by omeprazole and lansoprazole, may increase the serum concentration of N-desmethylclozapine, which can accumulate in lymphocytes and may achieve toxic levels. norclozapine cytochrome P450 family 1 subfamily A member 2 Homo sapiens