Title : Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts.

Pub. Date : 2017 May 15

PMID : 28288820






3 Functional Relationships(s)
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1 We found that BK-induced COX-2 protein and mRNA expression associated with PGE2 synthesis, and promoter activity was mediated through B2R receptors, which were attenuated by selective B2R antagonist Hoe140 or transfection with B2R siRNA. Dinoprostone kininogen 1 Homo sapiens
2 Up-regulation of Sirt1 by resveratrol suppressed the BK-induced COX-2/PGE2 production through inhibiting the interaction of AP-1 and NF-kappaB with COX-2 promoter in RASFs. Dinoprostone kininogen 1 Homo sapiens
3 BK-induced COX-2/PGE2 expression is mediated through a B2R-PKCmu-dependent MAPKs, AP-1, and NF-kappaB cascade. Dinoprostone kininogen 1 Homo sapiens