Pub. Date : 2017 May
PMID : 28282785
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Peimine inhibits hERG potassium channels through the channel inactivation states. | verticine | ETS transcription factor ERG | Homo sapiens |
| 2 | Thus, Peimine was chosen to investigate its inhibitory effects on hERG channels. | verticine | ETS transcription factor ERG | Homo sapiens |
| 3 | RESULTS AND CONCLUSION: We found that Peimine inhibited the hERG peak tail currents in a concentration dependent manner with an IC50 value of 43.7muM (n=4) by whole cell patch clamp techniques. | verticine | ETS transcription factor ERG | Homo sapiens |
| 4 | Mutation of Y652 to Alanine reduced sensitivity to Peimine, suggesting that Y652 is an important hERG binding sites for Peimine. | verticine | ETS transcription factor ERG | Homo sapiens |
| 5 | Mutation of Y652 to Alanine reduced sensitivity to Peimine, suggesting that Y652 is an important hERG binding sites for Peimine. | verticine | ETS transcription factor ERG | Homo sapiens |