Pub. Date : 2017
PMID : 28280524
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The increased intracellular ROS caused by mechanical injury stimulates PGE2 production in a time-dependent manner via the activation of cyclooxygenase-2 (COX-2), which was stimulated by phosphorylation of extracellular signal-regulated protein kinase (ERK). | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | The increased intracellular ROS caused by mechanical injury stimulates PGE2 production in a time-dependent manner via the activation of cyclooxygenase-2 (COX-2), which was stimulated by phosphorylation of extracellular signal-regulated protein kinase (ERK). | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | These results indicate ROS-induced ERK activation leading to the activation of COX-2 and the synthesis of PGE2 in human keratinocytes responding to mechanical injury in the acute phase. | Reactive Oxygen Species | mitogen-activated protein kinase 1 | Homo sapiens |