Title : Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.

Pub. Date : 2017 Jun

PMID : 28280079






1 Functional Relationships(s)
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1 ALDH1A1- cell lines as well as primary leukemia cells were found to be sensitive to treatment with compounds that directly and indirectly generate toxic ALDH substrates including 4-hydroxynonenal and the clinically relevant compounds arsenic trioxide and 4-hydroperoxycyclophosphamide. Arsenic Trioxide aldehyde dehydrogenase family 3, subfamily A1 Mus musculus