Title : Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells.

Pub. Date : 2017 Feb

PMID : 28272690






4 Functional Relationships(s)
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1 Licorice and its active compound glycyrrhizic acid ameliorates cisplatin-induced nephrotoxicity through inactivation of p53 by scavenging ROS and overexpression of p21 in human renal proximal tubular epithelial cells. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ROS)-mediated p53 activation. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 Cisplatin-induced apoptosis in renal cells is associated with reactive oxygen species (ROS)-mediated p53 activation. Reactive Oxygen Species tumor protein p53 Homo sapiens
4 CONCLUSIONS: These results suggest that LE and GA ameliorate cisplatin-induced apoptosis through reduction of ROS-mediating p53 activation and promotion of p21 expression in HK-2 cells. Reactive Oxygen Species tumor protein p53 Homo sapiens