Title : Chemosensitivity of MCF-7 cells to eugenol: release of cytochrome-c and lactate dehydrogenase.

Pub. Date : 2017 Mar 8

PMID : 28272477






3 Functional Relationships(s)
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1 Expression levels of both anti- and pro-apoptotic markers (Bcl-2 and Bax, respectively) decreased with increasing eugenol concentration, with no variation in their relative ratios. Eugenol BCL2 apoptosis regulator Homo sapiens
2 Eugenol-treated MCF-7 cells overexpressing Bcl-2 exhibited results similar to those of MCF-7. Eugenol BCL2 apoptosis regulator Homo sapiens
3 Our findings indicate that eugenol toxicity is non-apoptotic Bcl-2 independent, affecting mitochondrial function and plasma membrane integrity with no effect on migration or invasion. Eugenol BCL2 apoptosis regulator Homo sapiens