Pub. Date : 2017 Apr 15
PMID : 28264926
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, ectopic expression of wild-type PRODH, but not enzymatically inactive forms, induced senescence associated with the increase in reactive oxygen species (ROS) and the accumulation of DNA damage. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |
| 2 | Furthermore, ectopic expression of wild-type PRODH, but not enzymatically inactive forms, induced senescence associated with the increase in reactive oxygen species (ROS) and the accumulation of DNA damage. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |
| 3 | Treatment with N-acetyl-L-cysteine, a ROS scavenger, prevented senescence induced by PRODH overexpression. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |
| 4 | These results indicate that PRODH plays a causative role in DNA damage-induced senescence through the enzymatic generation of ROS. | Reactive Oxygen Species | proline dehydrogenase 1 | Homo sapiens |