Pub. Date : 2017 Jul 6
PMID : 28263966
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Our present study, for the first time to the best of our knowledge, discovered that environmental carcinogen nickel exposure led to MEG3 downregulation, consequently initiating c-Jun-mediated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation upregulation, in turn resulting in malignant transformation of human bronchial epithelial cells. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Moreover, HIF-1alpha protein translation was upregulated via activating the Akt/p70S6K/S6 axis resultant from PHLPP1 inhibition in nickel responses. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Collectively, we uncover that nickel exposure results in DNMT3b induction and MEG3 promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun and in turn increasing c-Jun inhibition of PHLPP1 transcription, leading to the Akt/p70S6K/S6 axis activation, and HIF-1alpha protein translation, as well as malignant transformation of human bronchial epithelial cells. | Nickel | hypoxia inducible factor 1 subunit alpha | Homo sapiens |