Title : Exposure of rats to exogenous endocrine disruptors 17alpha-ethinylestradiol and benzo(a)pyrene and an estrogenic hormone estradiol induces expression of cytochromes P450 involved in their metabolism.

Pub. Date : 2016 Dec 18

PMID : 28263535






2 Functional Relationships(s)
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1 METHODS: Changes in CYP protein expression after exposure of rats to BaP, EE2 or estradiol were analyzed by Western blotting. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 RESULTS: Whereas exposure to BaP induces expression of CYP1A1 protein and its marker activity (Sudan I oxidation) in liver, kidney and lung of rats, no significant induction of this CYP and its enzyme activity was produced by EE2 and estradiol. Benzo(a)pyrene cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus