Pub. Date : 2017 Aug
PMID : 28254657
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells. | Glutathione | glutathione S-transferase pi 1 | Homo sapiens |
| 2 | Eighty % reduction of intracellular glutathione (GSH) by buthionine sulfoximine (BSO), largely enhanced the sensitivity of the GSTP1 expressing MDA-MB-231 cells to HYP-PDT, but not in MCF7 cells. | Glutathione | glutathione S-transferase pi 1 | Homo sapiens |
| 3 | HYP loading studies suggested that HYP can be a substrate of GSTP for GSH conjugation as BSO enhanced the cellular HYP accumulation by 20% in MDA-MB-231 cells, but not in MCF7 cells. | Glutathione | glutathione S-transferase pi 1 | Homo sapiens |
| 4 | This means that the GSTP-lacking MCF7 may use L-cysteine for xenobiotic detoxification, especially during GSH synthesis inhibition, which leads to L-cysteine build-up. | Glutathione | glutathione S-transferase pi 1 | Homo sapiens |