Title : A molecular dynamics simulation study decodes the early stage of the disassembly process abolishing the human SAMHD1 function.

Pub. Date : 2017 May

PMID : 28251415






1 Functional Relationships(s)
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1 The human sterile alpha motif SAM and HD domain-containing protein 1 (SAMHD1) restricts in non-cycling cells type the infection of a large range of retroviruses including HIV-1, reducing the intracellular pool concentration of deoxynucleoside triphosphates (dNTPs) required for the reverse transcription of the viral genome. deoxynucleoside triphosphates SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 Homo sapiens