Title : Histamine-producing cell-stimulating activity. Interleukin 3 and granulocyte-macrophage colony-stimulating factor induce de novo synthesis of histidine decarboxylase in hemopoietic progenitor cells.

Pub. Date : 1987 Dec 1

PMID : 2824613






4 Functional Relationships(s)
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1 Both interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce increased histamine production by murine hemopoietic cells. Histamine interleukin 3 Mus musculus
2 In addition, maximal increase in histamine production in response to IL-3 is always higher than in response to GM-CSF. Histamine interleukin 3 Mus musculus
3 However, both mediators act by inducing the transcription of the HDC gene and de novo synthesis of this enzyme since actinomycin D or cycloheximide abolish GM-CSF-or IL-3-induced histamine-producing cell-stimulating activity. Histamine interleukin 3 Mus musculus
4 Finally, the observation that cholera toxin, prostaglandin E2, and N6,2"-O-dibutyryl adenosine 3",5"-cyclic monophosphate mimic the effects of IL-3 and GM-CSF on bone marrow cell HDC suggests an involvement of cyclic adenosine monophosphate in factor-induced histamine-producing cell-stimulating activity. Histamine interleukin 3 Mus musculus