Pub. Date : 2017 Feb 24
PMID : 28245593
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor. | Dinoprostone | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | TNFalpha and PGE2 increased the expression of RANKL, NFAT cytoplasmic-1 (NFATc1), cAMP response element-binding protein (CREB), and cyclooxygenase 2 (COX2); which increment was suppressed by indomethacin, a COX inhibitor. | Dinoprostone | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | PGE2 induced the binding of CREB to the RANKL promoter, whereas TNFalpha increased the binding of both CREB and NFATc1 to this promoter through a process blocked by indomethacin. | Dinoprostone | cAMP responsive element binding protein 1 | Mus musculus |