Pub. Date : 2017 Feb 24
PMID : 28245593
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNFalpha Increases RANKL Expression via PGE2-Induced Activation of NFATc1. | Dinoprostone | tumor necrosis factor | Mus musculus |
| 2 | TNFalpha increased prostaglandin E2 (PGE2) production, which in turn enhanced NFAT transcriptional activity and binding to the RANKL promoter. | Dinoprostone | tumor necrosis factor | Mus musculus |
| 3 | TNFalpha increased prostaglandin E2 (PGE2) production, which in turn enhanced NFAT transcriptional activity and binding to the RANKL promoter. | Dinoprostone | tumor necrosis factor | Mus musculus |
| 4 | These results suggest that TNFalpha-induced RANKL expression depends on PGE2 production and subsequent transcriptional activation/enhanced binding of NFATc1 and CREB to the RANKL promoter. | Dinoprostone | tumor necrosis factor | Mus musculus |