Pub. Date : 2017
PMID : 28243063
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel 5-oxo-hexahydroquinoline derivatives: design, synthesis, in vitro P-glycoprotein-mediated multidrug resistance reversal profile and molecular dynamics simulation study. | 5-oxo-hexahydroquinoline | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C4 and various carboxamide substituents at C3 were designed, synthesized and evaluated for their ability to inhibit P-gp by measuring the amount of rhodamine 123 (Rh123) accumulation in uterine sarcoma cells that overexpress P-gp (MES-SA/Dx5) using flow cytometry. | 5-oxo-hexahydroquinoline | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In this study, 26 novel 5-oxo-hexahydroquinoline derivatives containing different nitrophenyl moieties at C4 and various carboxamide substituents at C3 were designed, synthesized and evaluated for their ability to inhibit P-gp by measuring the amount of rhodamine 123 (Rh123) accumulation in uterine sarcoma cells that overexpress P-gp (MES-SA/Dx5) using flow cytometry. | 5-oxo-hexahydroquinoline | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The findings of this study show that some 5-oxo-hexahydroquinoline derivatives could serve as promising candidates for the discovery of new agents for P-gp-mediated MDR reversal. | 5-oxo-hexahydroquinoline | ATP binding cassette subfamily B member 1 | Homo sapiens |