Title : Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

Pub. Date : 2017 Jun

PMID : 28238856






1 Functional Relationships(s)
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1 Additionally, proliferative, but not growth-arrested BAEC, are sensitive to gemcitabine-induced apoptotic death, an effect blocked by inhibiting ASMase with imipramine or by binding ceramide on the cell surface with an anti-ceramide Ab. Imipramine sphingomyelin phosphodiesterase 1 Homo sapiens