Title : cAMP signaling increases histone deacetylase 8 expression via the Epac2-Rap1A-Akt pathway in H1299 lung cancer cells.

Pub. Date : 2017 Feb 24

PMID : 28232663






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In conclusion, the Epac-Rap1-Akt pathway mediates cAMP signaling-induced inhibition of JNK-dependent HDAC8 degradation, and the resulting HDAC8 increase augments cisplatin-induced apoptosis by repressing TIPRL expression in H1299 lung cancer cells. Cyclic AMP mitogen-activated protein kinase 8 Homo sapiens