Pub. Date : 2017 May
PMID : 28232172
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Conversion of cholesterol into sharp edges of cholesterol crystals (CCs) in alcohol intake was key to activation of NLRP3 inflammasome, induction of cerebral atherosclerosis, and development of neuropathy around the atherosclerotic lesions. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Thus, we observed that alcohol consumption elevated the level of plasma cholesterol, deposition and crystallization of cholesterol, as well as activation of NLRP3 inflammasome. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | We demonstrated the molecular mechanisms of NLRP3 activation and downstream signaling cascade event in primary culture of human brain arterial/capillary endothelial cells in the setting of dose-/time-dependent effects of alcohol/CCs using NLRP3 gene silencing technique. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | We demonstrated the molecular mechanisms of NLRP3 activation and downstream signaling cascade event in primary culture of human brain arterial/capillary endothelial cells in the setting of dose-/time-dependent effects of alcohol/CCs using NLRP3 gene silencing technique. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | We conclude that alcohol-induced accumulation and crystallization of cholesterol activates NLRP3/caspase-1 in the cerebral vessel that leads to early development of atherosclerosis. | Alcohols | NLR family pyrin domain containing 3 | Homo sapiens |