Pub. Date : 2017 Feb 23
PMID : 28231806
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. | Imatinib Mesylate | glutamic-oxaloacetic transaminase 2 | Homo sapiens |
| 2 | BACKGROUND: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. | Imatinib Mesylate | glutamic-oxaloacetic transaminase 2 | Homo sapiens |
| 3 | Treatment with imatinib resulted in similar pO2-levels in all three tumor models but only in KAT-4 tumors did the increase reach statistical significance. | Imatinib Mesylate | glutamic-oxaloacetic transaminase 2 | Homo sapiens |
| 4 | It is likely that after imatinib treatment the increase in pO2 in KAT-4 tumors is caused by increased blood flow due to reduced vascular resistance. | Imatinib Mesylate | glutamic-oxaloacetic transaminase 2 | Homo sapiens |
| 5 | This notion is supported by the significant reduction observed in IFP in KAT-4 tumors after imatinib treatment. | Imatinib Mesylate | glutamic-oxaloacetic transaminase 2 | Homo sapiens |