Title : Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a.

Pub. Date : 2017 Apr

PMID : 28220348






4 Functional Relationships(s)
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1 The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the proapoptotic targets of p53 were transcriptionally upregulated only in the p53 wild-type cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
2 The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the proapoptotic targets of p53 were transcriptionally upregulated only in the p53 wild-type cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
3 The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the proapoptotic targets of p53 were transcriptionally upregulated only in the p53 wild-type cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens
4 The resulted showed that MG132 induced significant apoptosis, and caused the accumulation of p53 protein in both p53 wild-type and mutant-type thyroid cancer cell lines, whereas the proapoptotic targets of p53 were transcriptionally upregulated only in the p53 wild-type cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor protein p53 Homo sapiens