Title : O2 metabolite-mediated injury in perfused kidneys is reflected by consumption of DMTU and glutathione.

Pub. Date : 1987 Oct

PMID : 2821829






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1 We found that addition of glucose oxidase (GO) or H2O2 to isolated perfused rat kidneys caused injury that was manifested by decreases in glomerular filtration rate, perfusion flow rate, and sodium reabsorption and that was prevented by addition of catalase (CAT) (but not inactivated CAT) or large doses of DMTU (15 mM), but not urea (15 mM). 1,3-dimethylthiourea catalase Rattus norvegicus