Pub. Date : 2017 May
PMID : 28208071
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anthocyanin suppresses CoCrMo particle-induced osteolysis by inhibiting IKKalpha/beta mediated NF-kappaB signaling in a mouse calvarial model. | Anthocyanins | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 2 | Furthermore, we confirmed that anthocyanin attenuated osteolysis by blocking NF-kappaB pathway via inhibiting inhibitor of nuclear factor kappa-B kinase alpha/beta (IKKalpha/beta) phosphorylation. | Anthocyanins | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |
| 3 | In conclusion, our study demonstrated that anthocyanin can protect against CoCrMo particle-induced inflammatory osteolysis via inhibiting the IKKalpha/beta-NF-kappaB pathway, and have a potential therapeutic effect on the treatment of wear particle-induced osteolysis. | Anthocyanins | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | Mus musculus |