Title : Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways.

Pub. Date : 2017 Apr 1

PMID : 28199510






1 Functional Relationships(s)
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1 In contrast, intravenous injection of oxLDL as well as high cholesterol diet for 6 weeks led to a switch from the Oct-1/SIRT1 signal transduction pathway to the ERK1/2 pathway and in turn to an enhanced thrombotic response with shortened occlusion time. Cholesterol mitogen-activated protein kinase 3 Mus musculus