Pub. Date : 2017 Mar
PMID : 28197642
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TGF-beta1/PTEN/PI3K signaling plays a critical role in the anti-proliferation effect of tetrandrine in human colon cancer cells. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |
| 2 | Tet exhibits no effect on total level of PTEN, but decreases the phosphorylation of PTEN; exogenous TGF-beta1 enhances the effect of Tet on decreasing the phosphorylation of PTEN, which was partly reversed by TGF-beta1 inhibitor. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |
| 3 | Tet exhibits no effect on total level of PTEN, but decreases the phosphorylation of PTEN; exogenous TGF-beta1 enhances the effect of Tet on decreasing the phosphorylation of PTEN, which was partly reversed by TGF-beta1 inhibitor. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |
| 4 | Tet exhibits no effect on total level of PTEN, but decreases the phosphorylation of PTEN; exogenous TGF-beta1 enhances the effect of Tet on decreasing the phosphorylation of PTEN, which was partly reversed by TGF-beta1 inhibitor. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |
| 5 | Tet exhibits no effect on total level of PTEN, but decreases the phosphorylation of PTEN; exogenous TGF-beta1 enhances the effect of Tet on decreasing the phosphorylation of PTEN, which was partly reversed by TGF-beta1 inhibitor. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |
| 6 | Our findings suggested that Tet may be a promising candidate for colon cancer treatment, and the anticancer activity may be mediated by inactivating PI3K/Akt signaling through upregulating TGF-beta1 to decrease the phosphorylation of PTEN. | tetrandrine | phosphatase and tensin homolog | Homo sapiens |