Title : Fibrinogen Kyoto III: a congenital dysfibrinogen with a gamma aspartic acid-330 to tyrosine substitution manifesting impaired fibrin monomer polymerization.

Pub. Date : 1989 Dec

PMID : 2819242






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The point mutation from an aspartic acid (pK for the beta-carboxyl = 3.86) to a tyrosine (pK for the aromatic hydroxyl = 10.07) may have perturbed the folding gamma chain structure in the D domain of fibrinogen specifically required for polymerization. Aspartic Acid fibrinogen beta chain Homo sapiens