Pub. Date : 2017 May
PMID : 28188924
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. | tert-Butylhydroperoxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. | tert-Butylhydroperoxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Furthermore, Daph exposure suppressed t-BHP-induced cytotoxicity and ROS overproduction, which are mostly blocked in Nrf2 knockout RAW 264.7 cells and peritoneal macrophages. | tert-Butylhydroperoxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK and ERK. | tert-Butylhydroperoxide | nuclear factor, erythroid derived 2, like 2 | Mus musculus |