Title : Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.

Pub. Date : 2017 Jun

PMID : 28188410






1 Functional Relationships(s)
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1 We also found that simvastatin attenuated IL-1beta-induced expression and MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5 activities and also reduced the decrease in type II collagen and aggrecan expression. Simvastatin ADAM metallopeptidase with thrombospondin type 1 motif 4 Homo sapiens