Pub. Date : 2017 Feb 10
PMID : 28187790
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid and TGF-beta signalling cooperate to overcome MYCN-induced retinoid resistance. | Tretinoin | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | We altered MYCN expression levels in a MYCN-inducible neuroblastoma cell line to facilitate or block retinoic acid (RA)-mediated neuronal differentiation. | Tretinoin | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | We altered MYCN expression levels in a MYCN-inducible neuroblastoma cell line to facilitate or block retinoic acid (RA)-mediated neuronal differentiation. | Tretinoin | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | Co-targeting of the retinoic acid and TGF-beta pathways, through RA and kartogenin (KGN; a TGF-beta signalling activating small molecule) combination treatment, induced the loss of viability of MYCN-amplified retinoid-resistant neuroblastoma cells. | Tretinoin | MYCN proto-oncogene, bHLH transcription factor | Homo sapiens |