Title : Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models.

Pub. Date : 2017

PMID : 28182747






1 Functional Relationships(s)
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1 The enzyme 5alpha-reductase was also revealed to be the predominant enzyme metabolizing 4-dione in LAPC-4 cells, yielding 5alpha-androstane-3,17-dione and not T. Other 17beta-HSDs than 17beta-HSD3 seem responsible in the androgen synthesis. Androstenedione hydroxysteroid 17-beta dehydrogenase 3 Homo sapiens