Title : Tris (1,3-dichloro-2-propyl) phosphate induces toxicity by stimulating CaMK2 in PC12 cells.

Pub. Date : 2017 Jun

PMID : 28181390






4 Functional Relationships(s)
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1 Furthermore, PC12 cells were pretreated with CaMK2 inhibitor KN93 to investigate the relationship between TDCIPP-induced phosphorylation of CaMK2 and activation of JNK, ERK1/2, and p38 MAPK pathways. tris(1,3-dichloro-2-propyl)phosphate mitogen activated protein kinase 3 Rattus norvegicus
2 Furthermore, PC12 cells were pretreated with CaMK2 inhibitor KN93 to investigate the relationship between TDCIPP-induced phosphorylation of CaMK2 and activation of JNK, ERK1/2, and p38 MAPK pathways. tris(1,3-dichloro-2-propyl)phosphate mitogen activated protein kinase 3 Rattus norvegicus
3 Our results indicate that TDCIPP-induced toxicity might be associated with the overload of [Ca2+ ]i levels, increased phosphorylation of CaMK2, and activation of the JNK, ERK1/2, and p38 MAPK pathways, the lattermost of which was further demonstrated to be partially elicited by the CaMK2 phosphorylation. tris(1,3-dichloro-2-propyl)phosphate mitogen activated protein kinase 3 Rattus norvegicus
4 Our results indicate that TDCIPP-induced toxicity might be associated with the overload of [Ca2+ ]i levels, increased phosphorylation of CaMK2, and activation of the JNK, ERK1/2, and p38 MAPK pathways, the lattermost of which was further demonstrated to be partially elicited by the CaMK2 phosphorylation. tris(1,3-dichloro-2-propyl)phosphate mitogen activated protein kinase 3 Rattus norvegicus