Title : Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.

Pub. Date : 2017 Jun 22

PMID : 28166201






2 Functional Relationships(s)
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1 Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, glycolysis and gluconeogenesis by conversion of mitochondrial oxaloacetate (OAA) to phosphoenolpyruvate, regulates glucose carbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)). Oxaloacetic Acid phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens
2 Here we show that mitochondrial phosphoenolpyruvate carboxykinase (PCK2), the hub molecule linking tricarboxylic acid (TCA) cycle, glycolysis and gluconeogenesis by conversion of mitochondrial oxaloacetate (OAA) to phosphoenolpyruvate, regulates glucose carbon flow direction in stem-like cells that repopulate tumors (tumor-repopulating cells (TRCs)). Oxaloacetic Acid phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens