Title : Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies.

Pub. Date : 2017 Dec

PMID : 28156185






3 Functional Relationships(s)
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1 RESULTS: DMF and MMF induced NQO1 and HO1 gene expression in ex vivo-stimulated PBMCs, DMF being the more potent inducer. Dimethyl Fumarate NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 Induction of NQO1 occurred at lower DMF concentrations compared to that of HO1. Dimethyl Fumarate NAD(P)H quinone dehydrogenase 1 Homo sapiens
3 In DMF-treated patients, a statistically significant induction of NQO1 was observed relative to baseline and compared to placebo. Dimethyl Fumarate NAD(P)H quinone dehydrogenase 1 Homo sapiens