Title : Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency.

Pub. Date : 2017 Feb 1

PMID : 28153093






1 Functional Relationships(s)
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1 Mechanistic insights into the process of VPA-induced reprogramming revealed that it was dependent on OCT4 promoter activation, which was achieved independently of the PI3K (phosphatidylinositol 3-kinase)/AKT/mTOR (mammalian target of rapamycin) pathway or GSK3beta inhibition but was concomitant with the presence of acetylated histones H3K9 and H3K56, which promote pluripotency. Valproic Acid glycogen synthase kinase 3 beta Homo sapiens