Title : NOX1 and NOX4 are required for the differentiation of mouse F9 cells into extraembryonic endoderm.

Pub. Date : 2017

PMID : 28152080






2 Functional Relationships(s)
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1 We identified the NADPH oxidase (NOX) complexes as candidates for the source of this endogenous ROS, and within this gene family, and over the course of differentiation, Nox1 and Nox 4 show the greatest upregulation induced by RA. Reactive Oxygen Species NADPH oxidase 1 Mus musculus
2 Thus, the data suggests that ROS produced during PrE differentiation is dependent in part on increased NOX1 and NOX4 levels, which is under the control of GATA6. Reactive Oxygen Species NADPH oxidase 1 Mus musculus