Title : Identification and Structural Characterization of the Precursor Conformation of the Prion Protein which Directly Initiates Misfolding and Oligomerization.

Pub. Date : 2017 Mar 24

PMID : 28147229






1 Functional Relationships(s)
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1 Structural and thermodynamic characterization by native-state hydrogen-deuterium exchange mass spectrometry studies indicate that the precursor conformation is a partially unfolded form of PrP that forms under misfolding-prone solvent conditions. Hydrogen prion protein Mus musculus