Pub. Date : 2017 Mar 7
PMID : 28146428
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia reduces testosterone synthesis in mouse Leydig cells by inhibiting NRF1-activated StAR expression. | Testosterone | nuclear respiratory factor 1 | Mus musculus |
| 2 | The purpose of this study is to determine NRF1 is involved in testosterone synthesis; and under hypoxia, the decrease of testosterone synthesis is caused by lower expression of NRF1. | Testosterone | nuclear respiratory factor 1 | Mus musculus |
| 3 | The purpose of this study is to determine NRF1 is involved in testosterone synthesis; and under hypoxia, the decrease of testosterone synthesis is caused by lower expression of NRF1. | Testosterone | nuclear respiratory factor 1 | Mus musculus |
| 4 | Overexpression and interference NRF1 could induced StAR and testosterone increased and decreased respectively. | Testosterone | nuclear respiratory factor 1 | Mus musculus |
| 5 | In conclusion, decline of NRF1 expression downregulated the level of StAR, which ultimately resulted in a reduction in testosterone synthesis. | Testosterone | nuclear respiratory factor 1 | Mus musculus |