Pub. Date : 2017 Mar 22
PMID : 28145544
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The results are consistent with: (i) at pH < 7.8, the square planar site in CuII-Abeta16 consists primarily of a bidentate ligand provided by the carboxylate sidechain of Asp1 and the N-terminal amine supported by the imidazole sidechains of two His residues (designated here as component IA); it is in equilibrium with a less stable component IB in which the carboxylate ligand is substituted by the Asp1-Ala2 carbonyl oxygen. | carboxylate | beta-secretase 2 | Homo sapiens |